01 - Heat a large skillet over medium-high heat. Add the ground beef, salt, black pepper, smoked paprika, and garlic powder. Cook, breaking up the meat and stirring occasionally, until browned and cooked through, about 7–8 minutes. Drain excess fat if needed.
02 - While the beef cooks, whisk together the mayonnaise, ketchup, mustard, pickle relish, apple cider vinegar, smoked paprika, salt, and pepper in a small bowl until smooth. Set aside.
03 - Divide the chopped romaine lettuce evenly among four large serving bowls.
04 - Top each bowl with equal portions of the cooked ground beef, cherry tomatoes, shredded cheddar cheese, red onion, pickle slices, and diced avocado.
05 - Drizzle each bowl with the prepared burger sauce just before serving. Serve immediately.